Scientists develop universal drug against viral infections

 Scientists have created an experimental mRNA-based drug that provides protection against multiple viruses, including coronavirus, according to a study published in Science.

The research drew on observations of people with a rare ISG15 protein deficiency, whose antiviral genes remain mildly but constantly active, making their cells more resistant to infections. Based on this phenomenon, scientists identified 10 key ISG genes that could deliver a “universal defense.”

The genes were delivered into lipid nanoparticles using mRNA technology and injected into animals. Tests showed significantly increased cellular resistance to Zika, vesicular stomatitis, influenza and SARS-CoV-2 viruses.

Researchers said maximum effectiveness was achieved only when all 10 genes were delivered together. While technical limitations remain in mRNA delivery, the study paves the way for universal antiviral drugs that could be used in broad infection prevention.

N.Tebrizli